Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during hela cell invasion

11Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

It has been recently shown that Trypanosoma cruzi trypomastigotes subvert a constitutive membrane repair mechanism to invade HeLa cells. Using a membrane extraction protocol and high-resolution microscopy, the HeLa cytoskeleton and T. cruzi parasites were imaged during the invasion process after 15 min and 45 min. Parasites were initially found under cells and were later observed in the cytoplasm. At later stages, parasite-driven protrusions with parallel filaments were observed, with trypomastigotes at their tips. We conclude that T. cruzi trypomastigotes induce deformations of the cortical actin cytoskeleton shortly after invasion, leading to the formation of pseudopod-like structures.

Cite

CITATION STYLE

APA

Fernandes, M. C., de Andrade, L. R., Andrews, N. W., & Mortara, R. A. (2011). Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during hela cell invasion. Memorias Do Instituto Oswaldo Cruz, 106(8), 1014–1016. https://doi.org/10.1590/S0074-02762011000800019

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free