Synthesis of Amino Acids Analogues of Citric Acid Siderophores

Abstract

Three amino acid analogues of citric acid siderophores were synthesized. The synthetic strategy involved condensation of 2-tert-butyl-l, 3-di(N-hydroxysuccinimidyl) or 2-tert-butyl-l, 3-bis(pentachlorophenyl)citrates with N-ethyl-w-aminoalkylhydroxamates. The examination of biological properties of the obtained compounds revealed their poor, if any side-rophore activity and thus confirmed the structural requirements previously suggested for side-rophores of this type. © 1991, Walter de Gruyter. All rights reserved.