PP.27 Micro-Vascular Disease at Booking in T1DM and Associated Risk of Developing Pre-Eclampsia

Abstract

Background and Aims Micro-vascular disease affects the majority of T1DM patients and is directly related to both duration and glycemic control of diabetes. The aim of this study is to identify the association of micro-vascular disease at booking and subsequent risk of developing pre-eclampsia during pregnancy. Methods Retrospective cohort study of women with T1DM (n = 37) on continuous subcutaneous insulin infusions booked at Guy's and St Thomas' Hospital between November 2010 and April 2012. Micro-vascular disease at booking was, defined as nephropathy or/and retinopathy at booking. Results The prevalence of micro-vascular disease at booking was 54.1% (n = 20). No significant difference were seen in age (33.5 years vs 35.0 years; p = 0.28), HbA1c (7.5 vs 6.9; p = 0.11), length of diabetes (16.0 years versus 23.0 years; p = 0.14) compared to women without micro-vascular disease. Presence of micro-vascular disease was significantly associated with the pre-eclampsia (55.0% vs 17.6%; p = 0.02; unadjusted OR 5.70; CI 1.24-26.26). This association was not explained by maternal age, duration or control of diabetes, parity, BMI and maternal hypertension (adjusted OR 4.92; CI 0.7-32.3). The rate of LGA and SGA was 51.3% and 5.4% respectively. Women with micro-vascular disease had higher rates of SGA (10.0% vs 0.0%; p < 0.05) and LGA (65.0% vs 35.0%; p < 0.05).