Temperature monitoring of internal body heating induced by decoupling pulses in animal 13C-MRS experiments

Abstract

A temperature monitoring method to promote safety with regard to tissue heating induced by RF irradiation during MRI procedures, especially carbon-13 magnetic resonance spectroscopy (13C-MRS), is proposed. The method is based on the temperature dependence of the water proton chemical shift (-0.01 ppm/°C) combined with phase mapping. Using this method, temperature changes were measured in rats (n = 4) employing practical 1H-decoupled 13C-MRS pulse sequences for 1D projections (TR = 1000 ms, acquisition time = 15 ms, matrix = 256, spatial resolution = 0.2 mm) and 2D images (TR = 1500 ms, acquisition time = 840 ms, matrix = 128 x 32, spatial resolution = 0.8 x 1.5 mm). Measurement error was 0.18°C (SD) for 1D acquisition and 0.39°C (SD) for 2D acquisition, demonstrating the feasibility of this temperature mapping method. Further studies should be conducted in human subjects to monitor patient safety and to optimize the pulse sequences employed. (C) 2000 Wiley- Liss, Inc.