Stress and stress responses: A narrative literature review from physiological mechanisms to intervention approaches

Abstract

Stress, an inevitable aspect of human existence, triggers complex physiological and behavioral responses aimed at maintaining internal equilibrium. It requires a multifaceted understanding encompassing its physiological, pathophysiological, and behavioral dimensions to inform effective treatment approaches. This narrative literature review attempts to understand the evolution of research on stress, from its historical roots to current physiological, pathophysiological, and conceptual understandings. Pathophysiological consequences of chronic stress, including cardiovascular disease and immune system dysregulation, highlight the need for comprehensive prevention and intervention strategies. The results demonstrate the importance of adopting a holistic approach to stress management, combining pharmacological interventions with psychological therapies such as cognitive-behavioral therapy and other third-wave approaches. For chronic stress, long-term strategies focusing on lifestyle modifications, social support, and coping skills enhancement are recommended, whereas acute stress may benefit from immediate pharmacological interventions to mitigate physiological arousal and promote relaxation. The review results also indicate the significance of the biopsychosocial framework in understanding stress by acknowledging its multifaceted nature, emphasizing the effectiveness and sustainability of diverse intervention strategies, and highlighting the role of societal factors in shaping stress experiences and treatment outcomes. Further research is warranted to clarify the mechanisms underlying stress responses and refine intervention strategies for optimal efficacy and sustainability.