1,4-Dihydropyridines as alkyl radical precursors: Introducing the aldehyde feedstock to nickel/Photoredox dual catalysis

Abstract

A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to Csp3-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores.