N-nitrosomethylurea-induced rat mammary tumours as models of human breast cancer

Abstract

A histopathological study is reported of the autopsy findings in two strains of rats treated with N-methyl-N-nitrosourea (MNU). The induced mammary tumours were histologically indistinguishable from those produced by dimethylbenz(a)anthracene (DMBA). A number of other primary tumours were found and there was no evidence of metastases.