Diagnostic consequences of cytomegalovirus glycoprotein B polymorphisms

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Abstract

Failure of a cytomegalovirus (CMV) real-time PCR assay targeting glycoprotein B (gB) was investigated. A multiplex assay targeting gB and immediate-early 2 (IE2) genes showed discordant results (gB negative and IE positive or a >10-fold-higher viral load with IE primers) in saliva from 14.6% of CMV-infected newborns. Sequencing revealed 3 patterns of gB variations. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

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Novak, Z., Chowdhury, N., Ross, S. A., Pati, S. K., Fowler, K., & Boppana, S. B. (2011). Diagnostic consequences of cytomegalovirus glycoprotein B polymorphisms. Journal of Clinical Microbiology, 49(8), 3033–3035. https://doi.org/10.1128/JCM.01039-11

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