Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine.

Abstract

1. Almitrine bismesylate displays wide inter‐subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine. 1991 The British Pharmacological Society