Synthesis, physico-chemical and spectral studies of mercury complex of glibenclamide, an oral antidiabetic drug

Abstract

Glibenclamide is a current, potent hypoglycemic agent used in NIDDM (non-insulin dependent Diabetes mellitus). Metal complexs of glibenclamide has been synthesised by reaction with mercury (II) in the form of its chloride. The conductometric titration using monovariation method indicates that complex is non-ionic and ML2 type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Analytical data agrees with the molecular formula (C23H28CIN3O5S) 2 Hg structure of the complex was assigned as tetrahedral in which ligand molecules lies horizontally joining the central mercury atom. Infrared spectral and molar conductance data confirm the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. Structure assigned to the complex is supported by analytical data, IR spectra and NMR spectra.