Ethanolic extract of Moringa oleifera leaves improve inflammation, angiogenesis, and blood pressure in rat model of preeclampsia

Abstract

The aim of this study is to investigate the effect of the ethanolic extract of Moringa oleifera leaves (EMOL) to improve inflammation, angiogenesis, and blood pressure by evaluating the serum level of IL-17, soluble vascular endothelial growth factor receptor 1 (sFlt-1), and blood pressure in a rat model of preeclampsia (PE). The rat model of PE was induced with Nω-nitro-L-arginine methyl ester (L-NAME) of 50 mg/kg body weight (b. w) on day 12-18 of gestation. On day 5 of gestation, three groups are given EMOL dose of 50,100, and 200 mg/kg b. w, and one group administered aspirin of 1.35 mg/200 g b.w. Blood pressure was measurement on days 0, 11, and 19 of gestation. On day 20 of gestation, the rats were sacrificed, and serum parameters were analyzed. There is a significant difference in the serum level of IL-17 in all of the groups (p 0.05). EMOL doses of 50 and 100 mg/kg b. w prevent an increase in the serum level of IL-17 better than low-dose aspirin (p 0.05). There was a tendency decrease in sFlt-1 serum levels with EMOL doses of 50 and 100 mg/kg b. w, but statistically there are no significant differences (p > 0.05). All the doses of EMOL have the same effect as low-dose aspirin to prevent blood pressure increase in the rat model of PE (p 0.05).