Consumer health benefits of habitual consumption of chlorogenic acid-enriched coffee: a large single-arm study

Abstract

Abdominal obesity is considered a fundamental cause of metabolic syndrome. It has been reported that continuous consumption of chlorogenic acid, which is a major component of coffee polyphenols, reduces abdominal fat together with body weight in humans. Chlorogenic acid-enriched ready-to-drink coffee has been developed recently. The antiobesity function of chlorogenic acid-enriched coffee has been demonstrated in some clinical trials; however, the efficacy of this coffee in daily life, which is more relevant in terms of consumer health, remains unknown. This paper describes a large single-arm study of the acceptability and effectiveness of chlorogenic acid-enriched coffee in terms of weight loss. Participants received one free carton (30 cans) of chlorogenic acid-enriched coffee and were encouraged to consume one can each day, and record their weight and coffee consumption using a web-based weight-recording system. The chlorogenic acid-enriched coffee showed high consumer acceptability. The mean weight change at Week 12 was −1.06 kg (95% confidence interval: −0.96, −1.16). Weight loss was significantly greater in obese participants compared with those with normal body mass index (<25 kg/m2) in both men and women. Changes in weight at Week 12 showed a significant dose-response relationship (p<0.001, n=1659). The habitual consumption of chlorogenic acid-enriched coffee together with the use of a weight-recording system was effective for achieving weight loss in daily life. The popularity of drinking coffee across all ages suggests a potentially substantial impact from substituting one cup of coffee a day with chlorogenic acid-enriched coffee.