New Piericidin Glucosides, Glucopiericidins a and B

Abstract

The new piericidin group antibiotics, glucopiericidins A and B were isolated from the culture broth of Streptomyces pactum S48727 (FERM P-8117) as co-metabolite of piericidin A1. The structures of glucopiericidins A and B were determined as piericidin and piericidin on the basis of their spectral and chemical pro-perties, respectively. Glucopiericidins were more potent in inhibiting antibody formation than piericidin A1 in vitro. In addition, these substances showed better antimicrobial activities than piericidin Al. Acute toxicities of these substances in mice were lower than that of piericidin A1. This indicates that D-glucose in glucopiericidin molecules is important in modulating their physiological activities. © 1987, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.