Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis

Abstract

Aims - To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis. Methods - Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a human MIF ELISA. Results - The average levels of MIF in the sera of patients with both acute and chronic iridocyclitis were significantly higher than that of healthy subjects. Conclusion - Uveitis induces the elevation of serum MIF, which may affect various inflammatory symptoms in uveitis.