Estimation of Bladder Pressure and Volume from the Neural Activity of Lumbosacral Dorsal Horn Using a Long-Short-Term-Memory-based Deep Neural Network

Abstract

In this paper, we propose a deep recurrent neural network (DRNN) for the estimation of bladder pressure and volume from neural activity recorded directly from spinal cord gray matter neurons. The model was based on the Long Short-Term Memory (LSTM) architecture, which has emerged as a general and effective model for capturing long-term temporal dependencies with good generalization performance. In this way, training the network with the data recorded from one rat could lead to estimating the bladder status of different rats. We combined modeling of spiking and local field potential (LFP) activity into a unified framework to estimate the pressure and volume of the bladder. Moreover, we investigated the effect of two-electrode recording on decoding performance. The results show that the two-electrode recordings significantly improve the decoding performance compared to single-electrode recordings. The proposed framework could estimate bladder pressure and volume with an average normalized root-mean-squared (NRMS) error of 14.9 ± 4.8% and 19.7 ± 4.7% and a correlation coefficient (CC) of 83.2 ± 3.2% and 74.2 ± 6.2%, respectively. This work represents a promising approach to the real-time estimation of bladder pressure/volume in the closed-loop control of bladder function using functional electrical stimulation.