Antimicrobial activities of alkaloids and lignans from Zanthoxylum budrunga

Abstract

Eight alkaloids (2-9) and two lignans (1 and 10) isolated from the stem bark of Zanthoxylum budrunga were tested against a panel of bacteria (both Gram positive and Gram negative) and fungi. Significant antibacterial activities were exhibited by all compounds against the test bacterial strains, except Klebsiella aerogenes. All compounds except the mixture of 2 and 3 showed reasonable antifungal activity against Aspergillus niger and Candida albicans. The MICs of the compounds against the test organisms were recorded in the range of 0.06-1.568 μmol.