Iodine–induced Oxidative Cyclisation of N-Acyl Amidines: A Rapid Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles

Abstract

A rapid and efficient metal-free synthesis of 3,5-disubstituted-1,2,4-oxadiazoles has been developed via iodine-induced oxidative cyclisation of N-acyl amidines. This eco-friendly approach allows wide functional group tolerance and results in the direct access of highly diversified 1,2,4-oxadiazoles in 59–94 % yields.