The toxicity of brown algae (Sargassum sp) extract to mice (Mus muscullus)

Abstract

Abstract OObbbjjective: The purpose of this study is to know the toxicity of brown algae extract sargassum sp given orally to mice. The research performed is an experimental laboratory research type with experimental post-test- only control group design. The research samples used are females white mice (mus musculus). Material and Methods: The demand of seaweed in the world increases due to increasing use of seaweed for various purpose in the field of industry, food, textile, paper, paints, cosmetics, medical and pharmaceutical field. Alginate is commonly used in the field of dentistry as printed materials to create study models. Materials in the field of dentistry must be biocompatible to the oral cavity tissues. The materials should be stable, safe, comfortable and certainly nontoxic to the oral cavity tissues and other tissues in human body. Treatment group 1 was given 500 mg/kg b.w. dose of sargassum sp, group 2 was given 1000 mg/Kg b.w. dose of sargassum sp, group 3 was given 1500 mg/Kg b.w. dose of sargassum sp, group 4 was given 2000 mg/Kg b.w. dose of sargassum sp and a control group was given only dose of Sodium carboxymethyl cellulose. Results: This study is a dose in humans that is converted into 2000 mg/Kg b.w. in mice, is a dose that does not cause the death of whole animals. Conclusion: Based on the acute toxicity category, the extracts of sargassum sp obtained from Punaga Takalar Regency, South Sulawesi contains mild toxicity.