Fcγ receptor IIa polymorphism in patients with brucellosis

Abstract

Recent evidence suggests that certain Fc gamma receptor (FcγR) alleles are genetic risk factors for infectious diseases. In this study, we evaluated FcγRIIa polymorphism in patients with brucellosis. In a case-control study, the frequency of two alleles and three genotypes for FcγRIIa were measured by PCR in 150 patients with brucellosis and 125 healthy controls. The H131 and R131 alleles were found in 133 (44.3%) and 167 patients (47.6%), respectively. The frequencies for the three genotypes (a/a, a/r, r/r) were 10 (6.7%), 113 (75.3%) and 27 (18%), respectively. There was no significant difference in the distribution of FcγRIIa genotypes and the two allelic forms between the patients and controls. Our study indicates that FcγRIIa polymorphism is not decisive for the acquisition of brucellosis.