HDAC5: Going with the flow

Abstract

In this issue of Blood, Wang and colleagues uncover a novel mechanism by which fluid shear stress regulates expression of endothelial genes through effects on HDAC5 phosphorylation. The endothelium of blood vessels serves important functions in normal physiology including regulation of vascular tone, endothelial cell survival, smooth muscle cell proliferation, leukocyte recruitment, and thrombosis.