Biginelli condensation of aldehydes, cyclopentanone and urea or thiourea in poly(ethylene)glycol 400, at 45°C in the presence of aluminum chloride as a highly efficient catalyst has been developed. The reaction is very fast, clean and environmentally benign for the synthesis of a vast variety of pyrimidinone derivatives.
CITATION STYLE
Amoozadeh, A., Rahmani, S., & Nemati, F. (2013). Poly(ethylene)glycol/AlCl3 as a new and efficient system for multicomponent Biginelli-type synthesis of pyrimidinone derivatives. Heterocyclic Communications, 19(1), 69–73. https://doi.org/10.1515/hc-2012-0157
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