Increased lipogenesis in cancer

Abstract

Cancer cells have adapted an altered metabolism to support their dysregulated proliferation. In human carcinoma, upregulation of several key enzymes involved in lipid synthesis is associated with tumor cell aggressiveness and a poor patient diagnosis. The phenomenon of elevated lipogenesis and lipogenic machinery in tumor cells has suggested lipogenic enzymes as potential diagnostic markers and therapeutic targets for cancer. © 2009 Landes Bioscience.