LRRK 2 to the rescue of damaged endomembranes

Abstract

Mutations in several genes encoding for lysosomal proteins are involved in Parkin- son’s disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine- rich repeat kinase 2 (LRRK2) is activated in response to pathogen or membranolytic drug-induced damage of phagolysosomes and lysosomes in macrophages, and regulates endolysosomal homeostasis by controlling the balance between membrane repair