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Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

Breast Cancer Research (2001) 3(2) 122-133
DOI: 10.1186/bcr284
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Abstract

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.

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Said, T. K., Moraes, R. C. B., Sinha, R., & Medina, D. (2001). Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth. Breast Cancer Research, 3(2), 122–133. https://doi.org/10.1186/bcr284

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