FAM135B sustains the reservoir of Tip60‐ATM assembly to promote DNA damage response

  • Zhang K
  • Wu Q
  • Liu W
  • et al.
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Abstract

Graphical Abstract 1. High levels of FAM135B are more resistant to genotoxic stress in vitro and in vivo. 2. FAM135B enhanced the interactions between TIP60 and ATM in resting conditions. 3. FAM135B will be released from the pre-assemble TIP60-ATM module for a rapid DNA damage response. Clin. Transl. Med. 2022;12:e945. wileyonlinelibrary.com/journal/ctm2 https://doi.

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Zhang, K., Wu, Q., Liu, W., Wang, Y., Zhao, L., Chen, J., … Zhan, Q. (2022). FAM135B sustains the reservoir of Tip60‐ATM assembly to promote DNA damage response. Clinical and Translational Medicine, 12(8). https://doi.org/10.1002/ctm2.945

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