Synthesis of some 3,5-diaryl-2-isoxazoline derivatives in ionic liquids media

Abstract

Biologically active isoxazoline derivatives were efficiently synthesized in excellent yields and in smaller reaction times using mild, effective and environmentally friendly butylmethylimidazolium bromide as the solvent and catalyst. By use of this catalyst, isoxazoline derivatives were produced via cyclization reaction of a chalcone and hydroxylamine hydrochloride in the ionic liquid media. The separation of the product was facile and the catalyst could be separated and recycled. The method is very rapid, safe and avoids the use of hazardous and expensive reagents and solvents.