Taste Masking of Pharmaceutical Formulations: Review on Technologies, Recent Trends and Patents

Abstract

The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have unpleasant or obnoxious taste. Taste is one of the important parameters which governs patient compliance and also decides the success of a product in the market. Undesirable taste or the bitter taste is a major challenge that formulation scientist faces with many drugs. Hence, oral administration  of bitter drugs is a big challenge,  especially for pediatric patients.  This article focuses on various tastes masking  techniques  by  which  the  characteristics  of  the  dosage  form  are  improved  and  better  patient  compliance  can  be achieved. The article also discusses various recent taste masking evaluation techniques used in oral pharmaceutical formulations. The pharmaceutical companies are now engaged in developing novel techniques to overcome the problem of taste masking by numerous patents filed for taste masking.  Lists of patents for taste masking are discussed and how these patents overcome the limitations of conventional approaches of taste masking is also reviewed. The present article also emphasizes various patented platform technologies based on different techniques used for taste masking. The important features and principles involved in taste-masking approaches of various patented technologies are also discussed. A better understanding of these new patents and patented technologies will help formulation scientists to select the most suited technology for development of new products with improved taste.