Rapid short-term reorganization in the language network

Abstract

The adaptive potential of the language network to compensate for lesions remains elusive. We show that perturbation of a semantic region in the healthy brain induced suppression of activity in a large semantic network and upregulation of neighbouring phonological areas. After perturbation, the disrupted area increased its inhibitory influence on another semantic key node. The inhibitory influence predicted the individual delay in response speed, indicating that inhibition at remote nodes is functionally relevant. Individual disruption predicted the upregulation of semantic activity in phonological regions. In contrast, perturbation over a phonological region suppressed activity in the network and disrupted behaviour without inducing upregulation. The beneficial contribution of a neighbouring network might thus depend on the level of functional disruption and may be interpreted to reflect a differential compensatory potential of distinct language networks. These results might reveal generic mechanisms of plasticity in cognitive networks and inform models of language reorganization.Taking part in a conversation requires us to extract meaning from a complex series of sounds by recognising words and phrases. We then need to decide on a response, and plan and execute the lip and tongue movements necessary to generate that response. Each of these processes – from analysing the meaning of words to producing speech – requires a distinct set of brain regions to work together. However, we know relatively little about how these regions interact with one another during specific language processes, or about what happens when key regions are damaged.Hartwigsen et al. have now used a technique called TMS in healthy volunteers to temporarily disrupt the activity of individual brain regions with a role in language. TMS involves applying small magnetic fields to the scalp over a target brain area. The magnetic fields induce electrical currents in the underlying brain tissue and temporarily scramble its activity. Hartwigsen et al. examined how this affected the volunteers’ performance on a language task, as well as the activity of other language areas.Temporarily disrupting a single brain region involved in analysing the meaning of words reduced the activity of multiple other areas in the brain’s language networks. The greater this reduction in activity, the more poorly the volunteers performed on a language task. However, not all brain regions showed reduced activity. Areas adjacent to the disrupted region, which normally process the sounds of words, increased their activity. This increase may have partially compensated for the effects of the TMS to help limit the language impairments.These findings offer insights into how the brain reacts and adapts when key language areas are damaged, for example as a result of stroke. The next step is to determine the extent to which healthy brain tissue can take over from damaged regions, and whether we can target this process to improve recovery after stroke.