A novel onco-miR-365 induces cutaneous squamous cell carcinoma

Abstract

The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cellsand clinical specimens of cutaneous squamous cell carcinoma(SCC). We demonstrated that the HaCaTpre-miR-365-2 cell line, whichoverexpressed miR-365, could induce subcutaneous tumors invivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibitedcutaneous tumor formation in vivo, along with G1 phase arrestand apoptosis of cancer cells. These findings suggest that miR-365 may act as an onco-miR in cutaneous SCC both in vitro andin vivo. The present study provides valuable insight into the roleof miR-365 in cutaneous SCC formation, which can help developnew drug and miR-365 target-based therapies for cutaneous SCC. © The Author 2013. Published by Oxford University Press.