Discoid lupus erythematosus and cutaneous squamous cell carcinoma

Abstract

Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disorder characterized by inflammatory skin lesions. Patients with DLE often exhibit photosensitivity, scarring, and a higher susceptibility to skin cancers. This systematic review aims to comprehensively evaluate the existing literature to better understand the relationship between DLE and cutaneous squamous cell carcinoma (cSCC). A systematic search of major medical databases was conducted to identify relevant studies published between 1978 and 2023. Studies were included if they explored the association between DLE and cSCC and reported epidemiological data, clinical features and outcomes. Evidence shows a correlation between DLE and squamous cell carcinoma. The study aimed to find literature about DLE and squamous cell carcinoma (SCC) and analyse potential risk factors. Healthcare providers should be aware of the increased cancer risk in DLE patients, emphasizing the importance of regular skin examinations and sun protection.