To determine if Butea superba Roxb., a traditional Thai male potency herb, has androgenic activity in 60-day-old male Wistar rats, we measured its effects on the pituitary-testicular axis and sex organs. Intact and orchidectomized adult male rats were subdivided into five groups (10 rats/group): distilled water, Butea superba (BS)-10, BS-50, BS-250, and testosterone propi-onate (TP). They received 0, 10, 50, and 250 mg·kg body weight-1·day-1 BS in distilled water by gavage and 6 mg·kg body weight-1·day-1 TP sc, respectively, during the 30-day treatment period. Blood was collected every 15 days and luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone were measured. Changes of weight and histological appearance of sex organs were determined at the end of the 30-day treatment and 15-day post-treatment periods. TP treatment reduced serum FSH and LH levels and signifcantly increased the weight of the seminal vesicles and epididymis, in accordance with histopathological changes, in both intact and orchidectomized rats. No changes in serum testosterone, LH, and FSH levels were observed in any of the intact rats treated with BS, but a signifcant increase in seminal vesicle weight was observed only in the BS-250 group. Although a signifcant reduction in serum LH was detected in the BS-50 and BS-250 groups of orchidectomized rats, no signifcant change in weight or histology of sex organs was observed. Thus, we conclude that B. superba needs endogenous testosterone to work synergistically to stimulate the accessory sex organ of intact animals and can potentially exhibit an LH reduction effect in orchidectomized animals.
CITATION STYLE
Malaivijitnond, S., Ketsuwan, A., Watanabe, G., Taya, K., & Cherdshewasart, W. (2010). Luteinizing hormone reduction by the male potency herb, Butea superba Roxb. Brazilian Journal of Medical and Biological Research, 43(9), 843–852. https://doi.org/10.1590/S0100-879X2010007500076
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