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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

Cell Chemical Biology (2020) 27(9) 1151-1163.e6
DOI: 10.1016/j.chembiol.2020.06.012
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Abstract

By using the affinity-directed protein missile (AdPROM) system comprised of VHL and high-affinity binders of GFP and H/K-RAS, Röth et al. demonstrate the targeted proteasomal degradation of GFP-K-RAS, which was knocked in using CRISPR/Cas9, and endogenous H/K-RAS.

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Röth, S., Macartney, T. J., Konopacka, A., Chan, K. H., Zhou, H., Queisser, M. A., & Sapkota, G. P. (2020). Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System. Cell Chemical Biology, 27(9), 1151-1163.e6. https://doi.org/10.1016/j.chembiol.2020.06.012

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