Effect of 7-Oryzanol on Experimental Liver Cirrhosis in Spontaneously Hypertensive Rats (SHR)

Abstract

The inhibitory effect of y-Oryzanol on liver cirrhosis induced by a high-fat diet in spontaneously hypertensive rats (SHRs) was investigated. Eight-week-old SHRs were fed a high-fat diet or a high-fat diet with y-Oryzanol for 3months. Lipogenic liver cirrhosis was induced in the animals fed the high-fat diet only. Incontrast, supplementation of the diet with y-Oryzanol suppressed liver cirrhosis and hyperlipidemia in the supplemented group. This study suggests that y-Oryzanol is very effective against lipogenic liver cirrhosis in the SHR, an animal which possesses natural abnormalities in lipid metabolism. © 1992, SOCIETY FOR FREE RADICAL RESEARCH JAPAN. All rights reserved.