The relationship between muscle quality index and physical function in older adults

Abstract

BACKGROUND: The muscle quality index (MQI) has been proposed as a diagnostic tool to detect individuals at risk of limited physical function. OBJECTIVE: Our goal was to examine the relationship of the MQI with physical function and compare its predictive ability with other muscle parameters of strength and mass in an older population. METHODS: Sixty-eight healthy older adults (34 male, 34 female) aged between 69 and 89 years were tested for body composition, MQI, maximum isokinetic concentric KES and physical function including sit-to-stand (STS) time, normal and maximum walking speed (WS), Timed Up and Go (TUG) and static balance. Pearson's correlation was applied to examine the relationship between muscle parameters. Linear regression analysis including age and sex as additional covariates was performed to assess their predictive ability for physical functions. RESULTS: MQI correlated significantly with relative KES (r= 0.611, p< 0.001), total KES (r= 0.829, p< 0.001) and leg lean tissue mass (r= 0.690, p< 0.001). The MQI was not a significant predictor for any physical function (p> 0.05). STS time was a significant predictor for normal WS and TUG time (p< 0.001). Relative KES was a significant predictor for all physical functions except static balance (p< 0.001). No muscle parameter and only age was a significant predictor for static balance. Models explained 20.4%-57.3% of variances of dependent variables. CONCLUSIONS: The MQI is a useful tool to assess leg lean tissue mass and strength of the knee extensor muscles and outperforms STS time. However, STS time and relative KES are more closely related to physical function than the MQI.