Antihypertensive effect of honey-based beverage containing fermented rice bran in spontaneously hypertensive rats

Abstract

The effect of oral administration of a honey-based beverage containing γ-aminobutyric acid (GABA)-fermented rice bran on blood pressure was investigated in spontaneously hypertensive rats. The control beverage or beverage containing GABA (10.1 mg/kg per day) was administered to 12-week-old male rats for 8 weeks. After 3 weeks administration, blood pressure in rats administered the GABA beverage was lower than that in the control group, while it was significantly decreased on week 7 (218 vs. 234 mmHg, P< 0.05). In conclusion, oral chronic administration of the GABA beverage to spontaneously hypertensive rats appears to be beneficial and may improve hypertension.