Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer

Abstract

We provide the first evidence demonstrating that single-nucleotide polymorphisms in macrophage function-related genes may predict prognosis in locoregional gastric cancer patients. Our results also suggest that the immune-related component of tumor for progression may be dictated not only by the malignant epithelial component but also by the genetic predisposition of host in gastric cancer.