Meiosis: The chromosomal foundation of reproduction

Abstract

Meiosis is the chromosomal foundation of reproduction, with errors in this important process leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the founding of the Society for the Study of Reproduction, the important chromosomal structures and dynamics contributing to genomic integrity across generations are highlighted. Critical unsolved biological problems are identified, and the advances that will lead to their ultimate resolution are predicted. Summary Sentence: The chromosomal dynamics that underlie meiosis, the defining event of gametogenesis, are reviewed, with a look forward to advances that are on the horizon.