Twin pregnancy and childbirth after reduced-intensity conditioning allogeneic haematopoietic stem cell transplantation combined with imatinib mesylate for chronic myeloid leukaemia: Case report and literature review

Abstract

The successful outcome of a pregnancy in a woman who had received reducedintensity conditioning (RIC) allogeneic haematopoietic stem cell transplantation (allo-HSCT) for chronic myeloid leukaemia is reported; publications on recovery of ovarian function and pregnancy following myeloablative conditioning (MAC) or RIC allo-HSCT for haematological disorders are reviewed. Research suggests that RIC allo-HSCT may facilitate ovarian recovery. Indeed, in the case study presented, the patient had a successful twin pregnancy and delivery, subsequent to treatment. After a 5-year follow-up, the patient survives disease-free with a sustained molecular response; her children are both healthy, with no physical defects. These findings suggest that RIC allo-HSCT combined with short-term imatinib mesylate does not necessarily have profound effects on female fertility. © SAGE Publications Ltd 2012.