Data-driven synthetic microbes for sustainable future

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Abstract

The escalating global environmental crisis demands transformative biotechnological solutions that are both sustainable and scalable. This perspective advocates Data-Driven Synthetic Microbes (DDSM); engineered microorganisms designed through integrating omics, machine learning, and systems biology to tackle challenges like PFAS degradation, greenhouse gas mitigation, and sustainable biomanufacturing. DDSMs offer a rational framework for developing robust microbial systems, reshaping the future of synthetic biology toward environmental resilience and circular bioeconomy.

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Mariam, I., Rova, U., Christakopoulos, P., Matsakas, L., & Patel, A. (2025). Data-driven synthetic microbes for sustainable future. Npj Systems Biology and Applications, 11(1). https://doi.org/10.1038/s41540-025-00556-4

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