Antidiabetic activity of vinca rosea extracts in alloxan-induced diabetic rats

Abstract

The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity. © 2010 Mohammed Fazil Ahmed et al.