Myology; Basic and Clinical

Abstract

3rd ed. This two volume set features over 100 color illustrations of clinical, pathological, and imaging studies in myology. It includes important information on muscular dystrophy and inflammatory disease as well as a better understanding of mitochondrial diseases and the genetic basis of inherited diseases. V. 1. Embryonic origins of skeletal muscles -- Assembly of the skeletal muscle cell -- Satellite and stem cells in muscle regeneration -- The diversity of muscle fiber types and its origin during development -- The structure and function of motor units -- Extraocular muscles -- Molecular structure of the sarcomere -- Mammalian muscle myosin -- Molecular physiology of the cross-bridge cycle -- Ion channels and electrical properties of skeletal muscle -- The membrane systems of muscle cells -- Excitation-contraction coupling in skeletal muscle -- Activation of the contractile mechanism by calcium -- The proteins of the sarcotubular system -- The neuromuscular junction -- Neuromuscular transmission -- Nicotinic acetylcholinesterase -- The cytoskeleton: maintenance of muscle fiber integrity -- The muscle fiber cytoskeleton: the dystrophin system -- The extracellular matrix -- The muscle spindle -- Microcirculation in muscle -- Protein and amino acid metabolism in muscle. Lysosomal metabolism and its relevance to skeletal muscle -- The clinical examination -- Electrodiagnosis of muscle disorders -- Muscle imaging -- Functional evaluation of metabolic myopathies -- The muscle biopsy -- Basic reactions of muscle -- Ultrastructural changes in diseased muscle -- Immune mechanisms in muscle diseases -- The tools of molecular genetics and their application to the study of muscle diseases -- V. 2. Dystrophinopathies -- Emery-Dreifuss muscular dystrophy -- Myotonic dystrophy -- The limb-girdle muscular dystrophies -- Facioscapulohumeral muscular dystrophy and scapuloperoneal disorders -- Bethlem myopathy -- Oculopharyngeal muscular dystrophy -- X-linked vacuolar myopathies -- Distal myopathies -- The congenital muscular dystrophies -- Cardiomyopathies associated with muscular dystrophies -- Nonystrophic myotonias and periodic paralyses -- Generalized peripheral nerve hyperexcitability (neuromyotonia) -- Hereditary inclusion body myopathies -- The polymyositis and dermatomyositis syndromes -- Inclusion body myositis -- Virus-related muscle diseases -- Parasitic myositis -- Other inflammatory myopathies. Congenital myopathies -- Nonlysosomal glycogenoses -- Acid maltase deficiency -- Disorders of lipid metabolism -- Mitochondrial encephalomyopathies -- Malignant hyperthermia -- Myoglobinura -- Myopathies due to drugs, toxins, and nutritional deficiency -- Endocrine myopathies -- Muscle pain, cramps, and fatigue -- Acquired autoimmune myasthenia gravis -- The Lambert-Eaton myasthenic syndrome -- Congenital myasthenic syndromes -- Spinal muscular atrophies -- Adult and juvenile amyotrophic lateral sclerosis and related motor neuron diseases -- Disease of peripheral nerves -- Congenital deformities.