Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function

Abstract

The paper by Sharyo et al. shows that statins reduce the severity in a model of renal-ischemia reperfusion injury and raises the therapeutic possibility of using statins as pharmacological intervention against acute kidney injury. This, together with previous studies, indicates that statins exert a wide spectrum of anti-inflammatory, immunomodulatory, and protective effects besides their lipid-lowering function.