Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: Mechanisms and applications

Abstract

Dynamic bone scanning with 99mTc-labeled diphosphonates and 18F-labeled sodium fluoride provides functional information sensitive for subtle changes in bone turnover and perfusion, which assists the clinical management of numerous osseous pathologies. This article reviews the mechanisms of uptake of 99mTc-labeled diphosphonates and 18F-sodium fluoride and discusses and compares the performance of these bone-seeking radiotracers for clinical and research applications, using dynamic and multiple-time-point imaging protocols and quantitative techniques. COPYRIGHT © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.