Abstract
Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1. © 1994.
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Kelly, S. L., Lamb, D. C., Taylor, M., Corran, A. J., Baldwin, B. C., & Powderly, W. G. (1994). Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiology Letters, 122(1–2), 39–42. https://doi.org/10.1111/j.1574-6968.1994.tb07140.x
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