Purtscher-like retinopathy related to drug-induced hypersensitivity syndrome

Abstract

Purpose: To report a case with Purtscher-like retinopathy related to drug-induced hypersensitivity syndrome (DIHS). Design: Case report. Methods: A 31-year-old male with fever, macula-papular rash, lymphadenopathy, and hepatitis was hospitalized. Results: Eosinophilic leukocytosis, as well as cotton wool spots around the optic disc, was observed. Viral, bacteriologic, and parasitologic tests and rheumatologic markers were all negative. Given his history of antibiotic use, he was diagnosed as DIHS. On the seventh day he lost consciousness and and on the tenth day he died. Conclusion: Purtscher-like retinopathy might be a sign of DIHS, and should be considered in the differential diagnosis where early intervention is needed. © 2012 Informa Healthcare USA, Inc.