Proteasome is vital for intracellular protein homeostasis as it eliminates mis-folded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmune diseases. In this review, recent developments of proteasome inhibitors for various diseases and related structure activity relationships are going to be summarized.
CITATION STYLE
Cao, Y., Zhu, H., He, R., Kong, L., Shao, J., Zhuang, R., … Zhang, J. (2020). Proteasome, a promising therapeutic target for multiple diseases beyond cancer. Drug Design, Development and Therapy. Dove Medical Press Ltd. https://doi.org/10.2147/DDDT.S265793
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