Recent biomimetic and organocataiytic syntheses of α-tocopherol

Abstract

We report here on our efforts to develop new strategies for the synthesis of α-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of α-tocopherol with overall up to 29% yield from commercially available material and up to 94% de. © Schweizerische Chemische Gesellschaft.