Regioselective C-3 arylation of coumarins with arylhydrazines via radical oxidation by potassium permanganate

Abstract

An efficient protocol for oxidative C-3 arylation of coumarins with arylhydrazine has been developed using potassium permanganate as an oxidant. The arylated coumarins with different electronic properties were obtained in moderate to good yields. The developed protocol for direct C-3 arylation of coumarins could be extended to quinolinones.