Sesquiterpenoid derivatives from Ferula ferulioides. IV

Abstract

Four novel prenyl-furocoumarin type sesquiterpenoid derivatives, 2,3- dihydro-7-hydroxy-2S*3R*-dimethyl-3-[4,8-dimethyl-3(E),7-nonadienyl]- furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-3-[4,8- dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy- 2S*,3R*-dimethyl-3-[4-methyl-5-(4-methyl-2-furyl)3(E)-pentenyl[-furo]3,2- c]coumarin, and 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-3-[4,8-dimethyl- 3(E),7-nonadienyl]-furo[3,2-c]coumarin were isolated from the roots of Ferula ferulioides. Their structures were established by detailed spectral analysis and the biosynthetic pathway leading to these prenyl-furocoumarin type sesquiterpenoids is proposed based on these structures.