Abstract
A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity. This journal is
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CITATION STYLE
Touchet, S., Chamberlain, K., Woodcock, C. M., Miller, D. J., Birkett, M. A., Pickett, J. A., & Allemann, R. K. (2015). Novel olfactory ligands via terpene synthases. Chemical Communications, 51(35), 7550–7553. https://doi.org/10.1039/c5cc01814e
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